HIV-1 GAG Sequence Summaries
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چکیده
HIVU53175 HIVCA9 U53175 422 bp gag Braaten, D. JVI 70, 4220 (1996) Comment: This study compared the five lineages of primate immunodeficiency viruses and found that only HIV-1 group M requires cyclophilin A for replication. HIV-1 gag binds to cyclophilin A and incorporates it into virions. If this process is disrupted, virion infectivity is inhibited. Cloned isolates from clades A, B, and D of HIV-1 group M and two clones from group O were used. This first phenotypic difference between group M and group O is consistent with the idea that the two HIV-1 groups were introduced to humans by different zoonotic transmissions. This sequence was obtained by PCR from human PBMCs infected with HIVCA9, a group O virus from Cameroon. GenBank accession number U53175.
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